Novel Bone Endocrine Networks Integrating Mineral and Energy Metabolism

Endocrine functions of bone in mineral metabolism regulation.

Given the dramatic increase in skeletal size during growth, the need to preserve skeletal mass during adulthood, and the large capacity of bone to store calcium and phosphate, juxtaposed with the essential role of phosphate in energy metabolism and the adverse effects of hyperphosphatemia, it is not surprising that a complex systems biology has evolved that permits cross-talk between bone and o...

Bone and Mineral Metabolism

Background: Evidence suggests that vitamin D status in adults is positively associated with calcium absorption fraction and inversely associated with serum PTH. The objective of this study was to evaluate the relationships among vitamin D status, PTH, and calcium absorption in midpubertal boys and girls. Methods: Calcium absorption was measured by using a stable isotope method in 93 young adole...

Endocrine regulation of bone and energy metabolism in hibernating mammals.

Precise coordination among organs is required to maintain homeostasis throughout hibernation. This is particularly true in balancing bone remodeling processes (bone formation and resorption) in hibernators experiencing nutritional deprivation and extreme physical inactivity, two factors normally leading to pronounced bone loss in non-hibernating mammals. In recent years, important relationships...

Dietary Casein on Bone and Mineral Metabolism

Clinical disorders of bone and mineral metabolism.

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